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Effects of Alismatis water extract (AE) on the blood pressure were investigate in the rabbit and the dog. AE, when administered into the vein of rabbit and dog, into the lateral ventricle of rabbit, produced fall of blood pressure. The depressor response of the rabbits to intravenous AE was abolished by treatment with atropine, but not with Avil, propranolol, methysergide. Pretreatment of rabbit with chlorisondamine weakened the depressor effect of AE. Intravenous AE in this rabbit produced secondary elevation of the blood pressure. AE potentiated the pressor response of the rabbit to norepinephrine and tyramine, but not to angiotensin, acetylcholine, and DMPP.
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